You or a family member can learn to give TRT injections at home. Injections are given into the muscle tissue, usually once a week or at longer intervals, as directed by your physician. Testosterone cypionate injections are safe and effective. Consideration should be given to the physician’s experience and preference, but also your preference. Choosing the type of testosterone therapy to use is a decision that should take several factors into account. There are several types of testosterone therapy including nasal sprays, topical gels that are rubbed into the skin, intramuscular injections, or pellets, which are inserted by a trained healthcare provider just beneath the skin. Types of Testosterone Replacement Therapy According to a study done by Clinical Endocrinology, using testosterone in conjunction with PDE5 Inhibitors can improve the erectile response by increasing blood flow. This allows hypogonadal men to improve their sexual function and increase response to ED treatments. Testosterone works by increasing libido and is necessary to develop an erection. Testosterone reverses the effects of apoptosis (cellular death) in the cavernosal smooth muscle cells. Primary male hypogonadism is caused by testicular dysfunction and can be congenital or develop as a man ages. Hypogonadism in a man is referred to as a decrease in either or both of the two major functions of the testicles: sperm and testosterone production. Testosterone can be used to treat erectile dysfunction when the main cause is an abnormal decrease in the body’s testosterone level, also known as hypogonadism or andropause. Some evidence also suggests testosterone replacement therapy can also lead to increased bone strength, improved blood sugar control, and a longer lifespan. Testosterone Replacement Therapy (TRT) can provide several benefits including increased sex drive and energy. Testosterone Replacement for Erectile Dysfunction